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TYLENOL 8 HR Arthritis Pain Extended Release Caplets temporarily relieves the minor pain of arthritis. With 650 milligrams of acetaminophen per caplet, this pain medicine also temporarily relieves aches and pains associated with muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, and toothache. From TYLENOL, the #1 doctor-recommended brand of pain relievers, these caplets also temporarily reduce fever. The bi-layer design delivers fast-acting relief that lasts up to eight hours.